Protein aggregation and neurodegeneration
نویسندگان
چکیده
منابع مشابه
Computational approaches to understanding protein aggregation in neurodegeneration.
The generation of toxic non-native protein conformers has emerged as a unifying thread among disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Atomic-level detail regarding dynamical changes that facilitate protein aggregation, as well as the structural features of large-scale ordered aggregates and soluble non-native oligomers, would contribute sign...
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A key molecular pathway implicated in diverse neurodegenerative diseases is the misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence strongly supports the hypothesis that accumulation of misfolded proteins leads to synaptic dysfunction, neuronal apoptosis, brain damage, and disease. However, the mechanism by which protein misfolding and aggregation trigger neu...
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Primer I n 1961, elegant experiments by Christian Anfinsen first demonstrated that a protein, the enzyme ribonuclease A, could be reversibly denatured (unfolded) and subsequently renatured (refolded) to its functional native state [1]. This and subsequent similar findings for many other proteins gave rise to a central tenet of protein folding, that the information specifying how a protein attai...
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ژورنال
عنوان ژورنال: Methods
سال: 2011
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2011.02.009